diff --git a/glance/common/config.py b/glance/common/config.py
index 487b78b265..e61d777930 100644
--- a/glance/common/config.py
+++ b/glance/common/config.py
@@ -782,7 +782,7 @@ def _get_deployment_config_file():
     path = CONF.paste_deploy.config_file
     if not path:
         path = _get_paste_config_path()
-    if not path:
+    if not path or not (os.path.isfile(os.path.abspath(path))):
         msg = _("Unable to locate paste config file for %s.") % CONF.prog
         raise RuntimeError(msg)
     return os.path.abspath(path)
diff --git a/glance/tests/unit/common/test_config.py b/glance/tests/unit/common/test_config.py
index 0888b0507f..d91c55f0a7 100644
--- a/glance/tests/unit/common/test_config.py
+++ b/glance/tests/unit/common/test_config.py
@@ -95,6 +95,13 @@ class TestPasteApp(test_utils.BaseTestCase):
         self._do_test_load_paste_app(expected_middleware,
                                      paste_config_file=paste_config_file)
 
+    def test_load_paste_app_with_paste_config_file_but_not_exist(self):
+        paste_config_file = os.path.abspath("glance-registry-paste.ini")
+        expected_middleware = oslo_middleware.Healthcheck
+        self.assertRaises(RuntimeError, self._do_test_load_paste_app,
+                          expected_middleware,
+                          paste_config_file=paste_config_file)
+
     def test_get_path_non_exist(self):
         self.assertRaises(RuntimeError, config._get_deployment_config_file)