diff --git a/ara/wsgi_sqlite.py b/ara/wsgi_sqlite.py
index a65d900a..b58a6ee4 100644
--- a/ara/wsgi_sqlite.py
+++ b/ara/wsgi_sqlite.py
@@ -51,22 +51,6 @@ import shutil
 import six
 import time
 
-if (int(os.getenv('ARA_WSGI_USE_VIRTUALENV', 0)) == 1 and
-   os.getenv('ARA_WSGI_VIRTUALENV_PATH')):
-    # Backwards compatibility, we did not always suffix activate_this.py
-    activate_this = os.getenv('ARA_WSGI_VIRTUALENV_PATH')
-    if 'activate_this.py' not in activate_this:
-        activate_this = os.path.join(activate_this, 'bin/activate_this.py')
-
-    if six.PY2:
-        execfile(activate_this, dict(__file__=activate_this))  # nosec
-    else:
-        exec(open(activate_this).read())  # nosec
-
-TMPDIR_MAX_AGE = int(os.getenv('ARA_WSGI_TMPDIR_MAX_AGE', 3600))
-LOG_ROOT = os.getenv('ARA_WSGI_LOG_ROOT', '/srv/static/logs')
-DATABASE_DIRECTORY = os.getenv('ARA_WSGI_DATABASE_DIRECTORY', 'ara-report')
-
 logger = logging.getLogger('ara.wsgi_sqlite')
 if not logger.handlers:
     logging.basicConfig(format='%(name)s:%(levelname)s:%(message)s')
@@ -86,6 +70,26 @@ def bad_request(environ, start_response, message):
 
 
 def application(environ, start_response):
+    # Apache SetEnv variables are passed only in environ variable
+    if (int(environ.get('ARA_WSGI_USE_VIRTUALENV', 0)) == 1 and
+       environ.get('ARA_WSGI_VIRTUALENV_PATH')):
+        # Backwards compatibility, we did not always suffix activate_this.py
+        activate_this = environ.get('ARA_WSGI_VIRTUALENV_PATH')
+        if 'activate_this.py' not in activate_this:
+            activate_this = os.path.join(activate_this, 'bin/activate_this.py')
+
+        if six.PY2:
+            execfile(activate_this, dict(__file__=activate_this))  # nosec
+        else:
+            exec(open(activate_this).read())  # nosec
+
+    TMPDIR_MAX_AGE = int(environ.get('ARA_WSGI_TMPDIR_MAX_AGE', 3600))
+    LOG_ROOT = environ.get('ARA_WSGI_LOG_ROOT', '/srv/static/logs')
+    DATABASE_DIRECTORY = environ.get(
+        'ARA_WSGI_DATABASE_DIRECTORY',
+        'ara-report'
+    )
+
     request = environ['REQUEST_URI']
     match = re.search('/(?P<path>.*/{}/)'.format(DATABASE_DIRECTORY), request)
     if not match:
diff --git a/doc/source/advanced.rst b/doc/source/advanced.rst
index 4abdbb61..bdb6142c 100644
--- a/doc/source/advanced.rst
+++ b/doc/source/advanced.rst
@@ -110,15 +110,55 @@ middleware. In order to do so, the vhost must look like the following::
       LogLevel warn
       CustomLog /var/log/httpd/logs.domain.tld-access.log combined
 
+      # Look out for the user/group which is different based on your distro
+      WSGIDaemonProcess ara user=apache group=apache processes=4 threads=1
+
       SetEnv ARA_WSGI_TMPDIR_MAX_AGE 3600
       SetEnv ARA_WSGI_LOG_ROOT /srv/static/logs
       SetEnv ARA_WSGI_DATABASE_DIRECTORY ara-report
-      WSGIDaemonProcess ara user=apache group=apache processes=4 threads=1
-      WSGIScriptAliasMatch ^.*/ara-report /var/www/cgi-bin/ara-wsgi-sqlite
+
+      <Directory "/usr/bin">
+        <Files "ara-wsgi-sqlite">
+          Require all granted
+        </Files>
+      </Directory>
+
+      # Redirect everything after /ara-report to the middleware
+      WSGIScriptAliasMatch ^.*/ara-report /usr/bin/ara-wsgi-sqlite
     </VirtualHost>
 
-You'll notice the ``WSGIScriptAliasMatch`` directive pointing to the WSGI
-script. This is bundled when installing ARA and can be copied to the location
-of your choice by doing::
+Using a virtual environment
+---------------------------
 
-    cp -p $(which ara-wsgi-sqlite) /var/www/cgi-bin/
+When using ARA from a virtual environment, you need to adjust your configuration
+accordingly.
+
+For example, your vhost might need to look like this instead::
+
+    <VirtualHost *:80>
+      # Remember that DocumentRoot and ARA_WSGI_LOG_ROOT must match
+      DocumentRoot /srv/static/logs
+      ServerName logs.domain.tld
+
+      ErrorLog /var/log/httpd/logs.domain.tld-error.log
+      LogLevel warn
+      CustomLog /var/log/httpd/logs.domain.tld-access.log combined
+
+      # Look out for the user/group which is different based on your distro
+      WSGIDaemonProcess ara user=apache group=apache processes=4 threads=1 python-home=/opt/venv/ara
+
+      SetEnv ARA_WSGI_USE_VIRTUALENV 1
+      SetEnv ARA_WSGI_VIRTUALENV_PATH /opt/venv/ara
+      SetEnv ARA_WSGI_TMPDIR_MAX_AGE 3600
+      SetEnv ARA_WSGI_LOG_ROOT /srv/static/logs
+      SetEnv ARA_WSGI_DATABASE_DIRECTORY ara-report
+
+      <Directory "/opt/venv/ara/bin">
+        <Files "ara-wsgi-sqlite">
+          Require all granted
+        </Files>
+      </Directory>
+
+      # Redirect everything after /ara-report to the middleware
+      WSGIScriptAliasMatch ^.*/ara-report /opt/venv/ara/bin/ara-wsgi-sqlite
+    </VirtualHost>